Senior Project Manager – PMO (GMP & non-GMP)

Summary Of Role
The Senior Project Manager – PMO is responsible for end-to-end delivery of sophisticated capital and infrastructure projects across AstraZeneca’s U.S. R&D network, including GMP and non-GMP facilities. This role leads projects from early concept through closeout, partnering with Site Leadership and Global stakeholders to define scope, evaluate infrastructure capacity and impacts, assess risk, and build capital strategy early in the lifecycle. The Senior Project Manager ensures initiatives are aligned with site strategy and executable within active, regulated environments. The role provides full project lifecycle accountability, scope, budget, schedule, risk, governance, and partner alignment, ensuring delivery of safe, compliant, and operationally sustainable facilities. The Senior Project Manager leads cross-functional teams including Senior Project Engineers, external design firms, contractors, Quality, SHE, and Facilities to ensure projects are implemented with operational excellence and regulatory integrity.
Responsibilities
Project Leadership & Accountability

Lead front end planning: scope definition, feasibility, infrastructure capacity assessments, and cost modeling.
Translate business needs into clearly defined charters, scope, and key assumptions.
Develop and defend capital investment cases, incorporating cost, risk, and lifecycle considerations.
Identify enabling projects, sequencing constraints, and long-term site impacts during early planning.
Lead capital projects from initiation through closeout within active GMP and R&D environments.
Own project scope, budget, schedule, and risk profile.
Lead capital forecasts, cash flow planning and financial tracking.
Ensure projects align with long-term site master planning strategy.
Governance & Compliance

Ensure adherence to PMO governance framework and stage-gate processes.
Establish early-stage risk identification and mitigation strategies to reduce downstream execution uncertainty.
Lead risk assessments and mitigation planning.
Lead prioritization and formal change management to protect cost and schedule commitments.
Ensure regulatory, safety, and environmental compliance throughout execution.
Raise and resolve project risks impacting cost, schedule or operational readiness.
Stakeholder & Cross-Functional Leadership

Serve as primary project interface for Site Leadership and Global partners.
Influence senior partners to align on scope definition, funding strategy, and risk tolerance.
Align Engineering, Quality, SHE, Procurement, and Operations throughout planning and execution.
Lead steering committee updates and executive reporting.
Drive strong collaboration between GMP and non-GMP pillars.
Contractor & Vendor Management

Lead selection and oversight of design firms and contractors.
Negotiate scope changes and lead contract performance.
Ensure safe execution and adherence to project controls.
GMP & Technical Integration

Partner with Senior Project Engineers to ensure technical rigor.
Ensure validation and regulatory expectations are coordinated early in project lifecycle.
Be responsible for commissioning and qualification strategy alignment.
Portfolio & Strategic Contribution

Support capital prioritization decisions through project definition and cost clarity.
Identify project interdependencies and sequencing risks across the capital portfolio.
Contribute to multi-year capital planning.
Identify program-level efficiencies and standardization opportunities.
Drive sustainability integration across project portfolio.
Experience And Education Requirements

Bachelor’s degree in Engineering, Construction Management, or related field.
10+ years of experience in capital project delivery in pharmaceutical/biotech or similar regulated industry.
Validated experience managing projects >$10M.
Strong financial competence and capital governance experience.
Experience leading cross-functional, multi-disciplinary teams.
Front End Project Strategy & Definition
Strategic Project Leadership
Financial & Capital Management
Executive Communication
Risk & Governance Discipline
Regulatory Awareness
Organizational Influence
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
The annual base pay for this position ranges from $122,859 to $184,289. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
Why AstraZeneca
Here you will help turn a rich, complex pipeline into real treatments by uniting science, disciplined execution, and smart digital tools. You will collaborate with unexpected teams that challenge ideas and accelerate progress, learning alongside peers who value kindness as much as ambition. With investment in cutting-edge capabilities and a clear focus on speed, quality, and sustainability, your leadership will shorten the path from study start-up to submission and, ultimately, to patients who need our medicines.
Call To Action
Step forward to lead the clinical programs that shape the next wave of medicines—send your CV today and help us deliver impact at speed!
Date Posted
01-Apr-2026
Closing Date
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.