Senior Engineer 2, Applied Artificial Intelligence

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We look forward to discovering your talents.
Welcome to an inspired career.
At Halozyme, we are reinventing the patient experience and building the future of drug delivery. We are passionate about the important work we do and constantly strive to do more. We embrace transformation and work hard to innovate for the future. We do this together, as One Team – we rise by lifting others up and believe in the power of working together for the collective win. That’s why we need you—to help us make a significant impact by taking on increasingly complex challenges, leaping beyond the status quo, advancing our mission and making our One Team culture thrive.
This role is located at our San Diego, CA site.
Join us as a Senior Engineer 2, Applied Artificial Intelligence, and you’ll be part of a culture that welcomes diversity, thinks differently to solve problems, works collaboratively as one team, and delivers meaningful innovations that impact people’s lives.
How You Will Make An Impact
The Senior Engineer 2, Applied AI builds and deploys AI solutions that directly support business workflows across Commercial, Regulatory, Quality, Finance, Operations, and Corporate functions. This role focuses on turning real business problems into working AI applications—including copilots, retrieval-augmented generation (RAG) solutions, document generation, automation agents, predictive models and decision-support tools. The Senior Engineer 2, Applied AI works closely with business SMEs, Data Engineering, and the AI Governance team to ensure solutions are secure, compliant, explainable, and production-ready in a regulated life-sciences environment.
In This Role, You’ll Have The Opportunity To

Build AI applications such as enterprise copilots, search assistants, document intelligence and generation tools, workflow-automation agents, predictive models, decision‑support tools, and reusable AI components including prompt libraries and solution patterns
Implement Retrieval-Augmented Generation (RAG) pipelines leveraging enterprise data sources such as SharePoint, data lakes, document repositories, and research systems
Build and maintain end‑to‑end AI/ML pipelines including data ingestion, feature engineering, model training, evaluation, deployment, and monitoring
Integrate LLMs into business workflows using APIs and platforms such as Azure OpenAI, OpenAI, Anthropic, and AWS Bedrock
Develop prompt-engineering, grounding, and evaluation frameworks to improve accuracy, reliability, and alignment
Translate business use cases across domains (e.g., medical affairs, regulatory, commercial, finance) into functional AI prototypes and production-ready applications
Collaborate with Data Scientists to scale models into production systems and with Product Owners/SMEs to refine requirements, acceptance criteria, and success metrics
Deploy and maintain AI solutions on cloud platforms using modern APIs and software‑engineering best practices
Implement MLOps and LLMOps capabilities including versioning, monitoring, logging, performance tracking, observability, and workload cost optimization
Implement guardrails and controls to prevent data leakage, hallucinations, and misuse
Integrate AI solutions with enterprise identity and data‑security frameworks, including RBAC, Purview, and related governance tools
Ensure all AI systems are reliable, scalable, and secure, and that they comply with data‑classification rules, privacy requirements, and AI governance policies
Key Skills

Applied AI/ML engineering
Prompt engineering & grounding techniques
Generative AI & LLM integration (Azure OpenAI, OpenAI, Anthropic, AWS Bedrock)
Enterprise data integration (SharePoint, data lakes, document repositories)
RAG architectures, vector databases, and semantic search
Cloud and API application development (Azure/AWS/GCP)
Python engineering
MLOps / LLMOps (monitoring, logging, versioning, observability, cost optimization)
Security‑aware engineering (RBAC, Purview, guardrails)
Responsible AI, governance, explainability, and data‑classification frameworks
Business problem‑solving & systems thinking
Strong stakeholder communication and cross‑functional collaboration
Preferred Experience

Experience with RAG pipelines, vector databases, and semantic search systems
Exposure to Azure OpenAI, Copilot Studio, LangChain, LlamaIndex, or similar AI frameworks
Familiarity with MLOps platforms such as MLflow, SageMaker, Azure ML, or Databricks
Experience working in regulated or data‑sensitive environments (e.g., pharma, healthcare, finance)
Knowledge of AI governance, Responsible AI, model explainability, and data‑classification standards
Experience building enterprise copilots, agentic AI systems, or intelligent automation solutions
To Succeed In This Role, You’ll Need

Bachelor’s degree in Computer Science, Engineering, Data Science, or related field, with at least 8 years of experience in software engineering, data engineering, or applied AI engineering (An equivalent combination of experience and education may be considered)
Strong proficiency in Python is required
Experience building and deploying applications using LLM APIs and AI solutions in cloud environments (Azure, AWS, or GCP)
Experience in Applied AI/ML & Prompt Engineering, Generative AI & LLM Integration, Enterprise Data Integration, API & Cloud Application Development, and Security-aware Engineering
Hands-on experience with ML frameworks (PyTorch, TensorFlow, scikit-learn)
Strong understanding of data engineering fundamentals, APIs, and distributed systems
Experience with RAG architectures, vector databases, and semantic search is preferred
Exposure to Azure OpenAI, Copilot Studio, LangChain, LlamaIndex, or similar frameworks is preferred
Familiarity with MLOps platforms (MLflow, SageMaker, Azure ML, Databricks) is preferred
Experience in regulated or data-sensitive environments (pharma, healthcare, finance) is preferred
Familiarity with AI governance, responsible AI, model explainability, and data classification is preferred
Experience building enterprise copilots or agentic AI solutions is preferred
In Return, We Offer You

Full and comprehensive benefit program, including an Employee Stock Purchase Program and 401(k) matching.
Opportunities to grow in a culture that prioritizes learning, development and progression through in-house programs and tuition reimbursement.
A collaborative, innovative team that works as one to amplify your impact—on your career, the work you do and patients’ lives.
The most likely base pay range for this position is $116K - $162K per year. Several factors, such as experience, tenure, skills, and particular business needs, will determine an individual’s exact level of compensation. Base salary is only one element of employee compensation at Halozyme. Total compensation could include bonuses, sales incentives, and equity awards.
Halozyme, Inc. is an Equal Employment Opportunity (EEO) employer. It is the policy of the Company to provide equal employment opportunities to all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.
Accessibility And Reasonable Accommodations
Halozyme is committed to providing reasonable accommodations for qualified individuals with disabilities and disabled veterans during our application process. If you need assistance or accommodation due to a disability, contact Human Resources at hrbox@halozyme.com.
To view all our open positions, please visit our career page. Additionally, our benefit offerings can be found here.