Associate Scientist II, Protein Sciences
Alnylam Pharmaceuticals
•
Cambridge, MA
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0
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Not Applicable
Posted April 2, 2026
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Responsibilities
Commitments
Responsibilities
- Work closely with the protein sciences team to engineer and validate binding of antibodies and antibody conjugates at various production scales.
- Design, plan, and perform protein binding experiments to support in vitro and in vivo evaluations, contributing to project-related scientific activities with some guidance from team members.
- Utilize UV–Vis spectroscopy and HPLC to analyze, quantify, characterize, and formulate protein conjugates.
- Contribute to the maintenance of laboratory infrastructure and equipment.
- Support group organization, productivity, and expertise through collaboration and idea exchange.
- Meet quality, quantity, and timeline expectations for all assigned projects.
- Support discovery efforts in protein sciences.
- Maintain accurate and complete electronic notebook records.
- Communicate experimental plans and data to multiple cross-functional scientific teams.
Commitments
This lab-based position is onsite and will be located at 675 W.
U.S.
Alnylam is an E-Verify Employer.
Not Met Priorities
What still needs stronger evidence
Requirements
- Familiarity with protein and/or antibody structure and function.
- Experience with protein binding techniches (ELISA, flow cytometry, SPR and/or BLI) preferred.
- Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, IEX, SDS-PAGE, UV–Vis spectroscopy) preferred.
- Passion for driving projects from the bench, independently contributing to research goals, and solving challenging problems.
- Detail-oriented, self-motivated, and comfortable working on highly technical projects in a multidisciplinary team setting.
- Effective written and oral communication skills.
- U.S.
Preferred Skills
- Experience with protein binding techniches (ELISA, flow cytometry, SPR and/or BLI) preferred.
- Experience with instrumentation such as Octet, Biacore, flow cytometers, and UV–Vis spectrometeters preferred.
- Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, IEX, SDS-PAGE, UV–Vis spectroscopy) preferred.
- Experience with sterile technique and/or handling mammalian cell culture is a plus.
- U.S.
Education
- (Not required) – BS/MS degree in biology, biochemistry, biophysics, chemistry, or a related field, with 0–1 years of relevant laboratory experience in a biopharma or academic setting.
Overview
We are seeking an associate scientist-II to join our protein sciences team to contribute to our protein production and conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in protein expression, purification, and analytical techniques, who are comfortable working in a fast-paced entrepreneurial environment. The successful candidate will be part of cross-functional teams including biologists, chemists, and pharmacologists and will contribute to advancing research programs across multiple therapeutic modalities
This lab-based position is onsite and will be located at 675 W. Kendall St. Cambridge, MA 02142
Key Responsibilities
Work closely with the protein sciences team to engineer and validate binding of antibodies and antibody conjugates at various production scales.
Design, plan, and perform protein binding experiments to support in vitro and in vivo evaluations, contributing to project-related scientific activities with some guidance from team members.
Utilize UV–Vis spectroscopy and HPLC to analyze, quantify, characterize, and formulate protein conjugates.
Contribute to the maintenance of laboratory infrastructure and equipment.
Support group organization, productivity, and expertise through collaboration and idea exchange.
Meet quality, quantity, and timeline expectations for all assigned projects.
Support discovery efforts in protein sciences.
Maintain accurate and complete electronic notebook records.
Communicate experimental plans and data to multiple cross-functional scientific teams.
Qualifications
BS/MS degree in biology, biochemistry, biophysics, chemistry, or a related field, with 0–1 years of relevant laboratory experience in a biopharma or academic setting.
Familiarity with protein and/or antibody structure and function.
Experience with protein binding techniches (ELISA, flow cytometry, SPR and/or BLI) preferred.
Experience with instrumentation such as Octet, Biacore, flow cytometers, and UV–Vis spectrometeters preferred.
Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, IEX, SDS-PAGE, UV–Vis spectroscopy) preferred.
Experience with sterile technique and/or handling mammalian cell culture is a plus.
Passion for driving projects from the bench, independently contributing to research goals, and solving challenging problems.
Detail-oriented, self-motivated, and comfortable working on highly technical projects in a multidisciplinary team setting.
Effective written and oral communication skills.
U.S. Pay Range
$67,600.00 - $101,400.00
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).
Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.
Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers
About Alnylam
We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.
We are seeking an associate scientist-II to join our protein sciences team to contribute to our protein production and conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in protein expression, purification, and analytical techniques, who are comfortable working in a fast-paced entrepreneurial environment. The successful candidate will be part of cross-functional teams including biologists, chemists, and pharmacologists and will contribute to advancing research programs across multiple therapeutic modalities
This lab-based position is onsite and will be located at 675 W. Kendall St. Cambridge, MA 02142
Key Responsibilities
Work closely with the protein sciences team to engineer and validate binding of antibodies and antibody conjugates at various production scales.
Design, plan, and perform protein binding experiments to support in vitro and in vivo evaluations, contributing to project-related scientific activities with some guidance from team members.
Utilize UV–Vis spectroscopy and HPLC to analyze, quantify, characterize, and formulate protein conjugates.
Contribute to the maintenance of laboratory infrastructure and equipment.
Support group organization, productivity, and expertise through collaboration and idea exchange.
Meet quality, quantity, and timeline expectations for all assigned projects.
Support discovery efforts in protein sciences.
Maintain accurate and complete electronic notebook records.
Communicate experimental plans and data to multiple cross-functional scientific teams.
Qualifications
BS/MS degree in biology, biochemistry, biophysics, chemistry, or a related field, with 0–1 years of relevant laboratory experience in a biopharma or academic setting.
Familiarity with protein and/or antibody structure and function.
Experience with protein binding techniches (ELISA, flow cytometry, SPR and/or BLI) preferred.
Experience with instrumentation such as Octet, Biacore, flow cytometers, and UV–Vis spectrometeters preferred.
Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, IEX, SDS-PAGE, UV–Vis spectroscopy) preferred.
Experience with sterile technique and/or handling mammalian cell culture is a plus.
Passion for driving projects from the bench, independently contributing to research goals, and solving challenging problems.
Detail-oriented, self-motivated, and comfortable working on highly technical projects in a multidisciplinary team setting.
Effective written and oral communication skills.
U.S. Pay Range
$67,600.00 - $101,400.00
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).
Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.
Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers
About Alnylam
We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.